Wednesday, May 15, 2019

Advanced pathophysiology Case Study Example | Topics and Well Written Essays - 750 words

Advanced pathophysiology - Case Study ExampleThe elevated WBC is from the proliferation of immature WBC which wrap up to increase, however do not mature (Harrison, 2011). The accumulation of immature white argumentation cells in the oculus sinister marrow and crease leads to the replacement of normal cells such as thrombocytes, which leads to thrombocytopenia and a disruption of blood clotting (Harrison, 2011). Therefore, this diligent presents with gum bleeding and easy bruising. In addition, decreased levels of leucocytes in any case increase the patients vulnerability to bruising. The replacement of cells also leads to a decrease in the number of red blood cells which are responsible for oxygen transport. This in turn is the reason why the patient developed become flat and shortness of breath may also have been present (Harrison, 2011). The splenomegaly occurs as a result of extamedullary hemogenesis as the bone marrow becomes less competent. The reduction of red blood cel ls due to replacement also leads to paleness. Upper abdominal tenderness could be attributed to splenomegaly. Opportunistic infections that occur as a result of the comprised immune system may lead to arthalgia. Describe pathophysiology of each(prenominal). Compare it with some other leukemia forms in children The increase of ALL is expect to occur as a result of alteration of a progenitor cell responsible for round-the-clock clonal expansion (Bassan & Hoelzer, 2011). This event piece of ass occur in cells of T of B cell course which give rise to contrasting types of acute lymphoblastic leukemia. These subtypes are based on the stage of cell development which the transformation occurred. Approximately 80% of ALL cases have been found to originate from B lymphocyte precursors (Onciu, 2009). round(prenominal) factors have been found to influence the development of this cancer and these include radiation exposure, genetics, chemical exposure and some viral infections such as HTLV-1 (Onciu, 2009). As mentioned above the alteration of the precursor cells leads to an arrest in development. This then leads to the proliferation of immature white blood cells in the bone marrow which replace its physiological components. Therefore, in that respect is a marked decrease in the formation of several blood elements. This may lead to other complications such as thrombocytopenia, anemia and neutropenia (Pui, Relling & Downing, 2004). In addition, the disruption of bone marrow function leads to extramedullary hematopoiesis which occurs in the spleen, liver and lymph nodes (Pui, Relling & Downing, 2004).These organs will then increase in size resulting in hepatomegaly and splenomegaly. This leukemia is different from AML which moves the myeloid blast cells whilst ALL involves lymphoblasts. In the pathogenesis of Acute Myeloid Leukemia, the pathological defect will involve numerous precursor cells which will develop immature (Pui, Relling & Downing, 2004). Meanwhile in Acute Lymphoblastic Leukemia, the effect is on a precursor cell that that will proliferate and produce several immature cells. The etiological factors amongst the two types of leukemia are also different. AML often occurs as a result of certain preleukemic blood disorders whilst ALL often associated with genetic factors and a prolonged exposure to radioactive substances (Pui, Relling & Downing, 2004). What is the purpose of chemotherapy in ALL? What is a common side effect of Therapy? Chemotherapy is necessary in this condition as the drugs are injected intravenously and can be used to treat cancerous cells that have

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